Publication: Hypoxic preconditioning protects photoreceptors against light damage independently of hypoxia inducible transcription factors in rods
Hypoxic preconditioning protects photoreceptors against light damage independently of hypoxia inducible transcription factors in rods
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Kast, B., Schori, C., & Grimm, C. (2016). Hypoxic preconditioning protects photoreceptors against light damage independently of hypoxia inducible transcription factors in rods. Experimental Eye Research, 146, 60–71. https://doi.org/10.1016/j.exer.2015.12.008
Abstract
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Hypoxic preconditioning protects photoreceptors against light-induced degeneration preserving retinal morphology and function. Although hypoxia inducible transcription factors 1 and 2 (HIF1, HIF2) are the main regulators of the hypoxic response, photoreceptor protection does not depend on HIF1 in rods. Here we used rod-specific Hif2a single and Hif1a;Hif2a double knockout mice to investigate the potential involvement of HIF2 in rods for protection after hypoxic preconditioning. To identify potential HIF2 target genes in rods we determ
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- Kast, Brigitte
- Schori, Christian
- Grimm, Christian
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Kast, B., Schori, C., & Grimm, C. (2016). Hypoxic preconditioning protects photoreceptors against light damage independently of hypoxia inducible transcription factors in rods. Experimental Eye Research, 146, 60–71. https://doi.org/10.1016/j.exer.2015.12.008
