Publication: Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanisms
Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanisms
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Moransard, M., Bednar, M., Frei, K., Gassmann, M., & Ogunshola, O. O. (2017). Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanisms. Journal of Neuroinflammation, 14:202. https://doi.org/10.1186/s12974-017-0976-5
Abstract
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Abstract
Treatment with erythropoietin (Epo) in experimental autoimmune encephalomyelitis (EAE), the rodent model of multiple sclerosis (MS), has consistently been shown to ameliorate disease progression and improve overall outcome. The effect has been attributed to modulation of the immune response and/or preservation of the central nervous system (CNS) tissue integrity. It remains unclear, however, if (a) Epo acts primarily in the CNS or the periphery and if (b) Epo’s beneficial effect in EAE is mainly due to maintaining CNS tissue integrity
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- Moransard, M
- Bednar, M
- Frei, K
- Gassmann, M
- Ogunshola, O O
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Moransard, M., Bednar, M., Frei, K., Gassmann, M., & Ogunshola, O. O. (2017). Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanisms. Journal of Neuroinflammation, 14:202. https://doi.org/10.1186/s12974-017-0976-5
