Publication: Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI
Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI
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Laudicella, R., Rüschoff, J. H., Ferraro, D. A., Brada, M. D., Hausmann, D., Mebert, I., Maurer, A., Hermanns, T., Eberli, D., Rupp, N. J., & Burger, I. A. (2022). Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI. European Journal of Nuclear Medicine and Molecular Imaging, 49(11), 3917–3928. https://doi.org/10.1007/s00259-022-05787-9
Abstract
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Purpose: Recently, a significant association was shown between novel growth patterns on histopathology of prostate cancer (PCa) and prostate-specific membrane antigen (PSMA) uptake on [68Ga]PSMA-PET. It is the aim of this study to evaluate the association between these growth patterns and ADC (mm2/1000 s) values in comparison to [68Ga]PSMA uptake on PET/MRI.
Methods: We retrospectively evaluated patients who underwent [68Ga]PSMA PET/MRI for staging or biopsy guidance, followed by radical prostatectomy at our institution between 07/20
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- Laudicella, Riccardo
- Rüschoff, Jan H
- Ferraro, Daniela A
- Brada, Muriel D
- Hausmann, Daniel
- Mebert, Iliana
- Maurer, Alexander
- Hermanns, Thomas
- Eberli, Daniel
- Rupp, Niels J
- Burger, Irene A
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Laudicella, R., Rüschoff, J. H., Ferraro, D. A., Brada, M. D., Hausmann, D., Mebert, I., Maurer, A., Hermanns, T., Eberli, D., Rupp, N. J., & Burger, I. A. (2022). Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI. European Journal of Nuclear Medicine and Molecular Imaging, 49(11), 3917–3928. https://doi.org/10.1007/s00259-022-05787-9
