Repetitive ocular vestibular evoked myogenic potential stimulation for the diagnosis of myasthenia gravis: Optimization of stimulation parameters

Wirth, Magdalena A; Valko, Yulia; Rosengren, Sally M; Schmückle-Meier, Tanja; Bockisch, Christopher J; Straumann, Dominik; Landau, Klara; Weber, Konrad P

doi:10.1016/j.clinph.2019.03.033

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Wirth, M. A., Valko, Y., Rosengren, S. M., Schmückle-Meier, T., Bockisch, C. J., Straumann, D., Landau, K., & Weber, K. P. (2019). Repetitive ocular vestibular evoked myogenic potential stimulation for the diagnosis of myasthenia gravis: Optimization of stimulation parameters. Clinical Neurophysiology, 130(7), 1125–1134. https://doi.org/10.1016/j.clinph.2019.03.033

Abstract

OBJECTIVE To determine the most effective stimulation parameters for the diagnosis of ocular myasthenia gravis (MG) using repetitive ocular vestibular evoked myogenic potentials (oVEMP) for quantification of the extraocular muscle response decrement. METHODS Repetitive bone-conducted oVEMPs were elicited in 18 MG patients and 20 healthy subjects. We compared four different stimulus repetition rates (20 Hz, 30 Hz, 40 Hz, 50 Hz) and 100 Hz continuous stimulation, as well as recordings from the inferior oblique muscles and the lateral re