Publication: RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells
RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells
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Urban, V., Dobrovolna, J., Hühn, D., Fryzelkova, J., Bartek, J., & Janscak, P. (2016). RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. Journal of Cell Biology, 214, 401–415. https://doi.org/10.1083/jcb.201507099
Abstract
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Abstract
Collisions between replication and transcription machineries represent a significant source of genomic instability. RECQ5 DNA helicase binds to RNA-polymerase (RNAP) II during transcription elongation and suppresses transcription-associated genomic instability. Here, we show that RECQ5 also associates with RNAPI and enforces the stability of ribosomal DNA arrays. We demonstrate that RECQ5 associates with transcription complexes in DNA replication foci and counteracts replication fork stalling in RNAPI- and RNAPII-transcribed genes, su
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- Urban, Vaclav
- Dobrovolna, Jana
- Hühn, Daniela
- Fryzelkova, Jana
- Bartek, Jiri
- Janscak, Pavel
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Urban, V., Dobrovolna, J., Hühn, D., Fryzelkova, J., Bartek, J., & Janscak, P. (2016). RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. Journal of Cell Biology, 214, 401–415. https://doi.org/10.1083/jcb.201507099
