Optimized procedures for testing plasma metanephrines in patients on hemodialysis

Pamporaki, Christina; Prejbisz, Aleksander; Małecki, Robert; Pistrosch, Frank; Peitzsch, Mirko; Bishoff, Steffen; Mueller, Petra; Meyer, Iris; Reimann, Doreen; Hanus, Katarzyna; Januszewicz, Andrzej; Bornstein, Stefan R; Parmentier, Simon; Kunath, Carola; Lenders, Jacques W M; Eisenhofer, Graeme; Passauer, Jens

doi:10.1038/s41598-021-94104-9

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Pamporaki, C., Prejbisz, A., Małecki, R., Pistrosch, F., Peitzsch, M., Bishoff, S., Mueller, P., Meyer, I., Reimann, D., Hanus, K., Januszewicz, A., Bornstein, S. R., Parmentier, S., Kunath, C., Lenders, J. W. M., Eisenhofer, G., & Passauer, J. (2021). Optimized procedures for testing plasma metanephrines in patients on hemodialysis. Scientific Reports, 11(1), 14706. https://doi.org/10.1038/s41598-021-94104-9

Abstract

Diagnosis of pheochromocytomas and paragangliomas in patients receiving hemodialysis is troublesome. The aim of the study was to establish optimal conditions for blood sampling for mass spectrometric measurements of normetanephrine, metanephrine and 3-methoxytyramine in patients on hemodialysis and specific reference intervals for plasma metanephrines under the most optimal sampling conditions. Blood was sampled before and near the end of dialysis, including different sampling sites in 170 patients on hemodialysis. Plasma normetanephr