Publication: Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV 2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case
Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV 2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case
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Tatham, L., Kipar, A., Sharp, J., Kijak, E., Herriott, J., Neary, M., Box, H., Gallardo Toledo, E., Valentijn, A., Cox, H., Pertinez, H., Curley, P., Arshad, U., Rajoli, R. K., Rannard, S., Stewart, J., & Owen, A. (2023). Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV 2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case (No. 477397; BioRxiv). https://doi.org/10.1101/2022.01.23.477397
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Background: Ronapreve demonstrated clinical application in post-exposure prophylaxis, mild/moderate disease and in the treatment of seronegative patients with severe COVID19 prior to the emergence of the Omicron variant in late 2021. Numerous reports have described loss of in vitro neutralisation activity of Ronapreve and other monoclonal antibodies for BA.1 Omicron and subsequent sub-lineages of the Omicron variant. With some exceptions, global policy makers have recommended against the use of existing monoclonal antibodies in COVID1
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Tatham, L., Kipar, A., Sharp, J., Kijak, E., Herriott, J., Neary, M., Box, H., Gallardo Toledo, E., Valentijn, A., Cox, H., Pertinez, H., Curley, P., Arshad, U., Rajoli, R. K., Rannard, S., Stewart, J., & Owen, A. (2023). Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV 2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case (No. 477397; BioRxiv). https://doi.org/10.1101/2022.01.23.477397
