Publication: Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes
Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes
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O’Connor, T., Frei, N., Sponarova, J., Schwarz, P., Heikenwalder, M., & Aguzzi, A. (2012). Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes. PLoS Pathogens, 8(8), e1002867. https://doi.org/10.1371/journal.ppat.1002867
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Abstract
Neuroinvasion and subsequent destruction of the central nervous system by prions are typically preceded by a colonization phase in lymphoid organs. An important compartment harboring prions in lymphoid tissue is the follicular dendritic cell (FDC), which requires both tumor necrosis factor receptor 1 (TNFR1) and lymphotoxin β receptor (LTβR) signaling for maintenance. However, prions are still detected in TNFR1(-/-) lymph nodes despite the absence of mature FDCs. Here we show that TNFR1-independent prion accumulation in lymph nodes de
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- O'Connor, Tracy
- Frei, Nathalie
- Sponarova, Jana
- Schwarz, Petra
- Heikenwalder, Mathias
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O’Connor, T., Frei, N., Sponarova, J., Schwarz, P., Heikenwalder, M., & Aguzzi, A. (2012). Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes. PLoS Pathogens, 8(8), e1002867. https://doi.org/10.1371/journal.ppat.1002867
