DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells

Bachmann, Samia B; Frommel, Sandra C; Camicia, Rosalba; Winkler, Hans C; Santoro, Raffaella; Hassa, Paul O

doi:10.1186/1476-4598-13-125

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Bachmann, S. B., Frommel, S. C., Camicia, R., Winkler, H. C., Santoro, R., & Hassa, P. O. (2014). DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. Molecular Cancer, 13, 125. https://doi.org/10.1186/1476-4598-13-125

Abstract

BACKGROUND: Prostate cancer (PCa) is one of the leading causes of cancer-related mortality and morbidity in the aging male population and represents the most frequently diagnosed malignancy in men around the world. The Deltex (DTX)-3-like E3 ubiquitin ligase (DTX3L), also known as B-lymphoma and BAL-associated protein (BBAP), was originally identified as a binding partner of the diphtheria-toxin-like macrodomain containing ADP-ribosyltransferase-9 (ARTD9), also known as BAL1 and PARP9. We have previously demonstrated that ARTD9 acts a