Publication: Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine
Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine
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Garrido, M., Skorucak, J., Raduazzo, D., Turco, M., Spinelli, G., Angeli, P., Amodio, P., Achermann, P., & Montagnese, S. (2016). Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine. Metabolic Brain Disease, 31(4), 965–974. https://doi.org/10.1007/s11011-016-9835-9
Abstract
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UNLABELLED Hyperammonaemia/mild hepatic encephalopathy (HE) can be simulated by the oral administration of a so-called amino acid challenge (AAC). This study sought to assess the effects of the AAC alone and in combination with either ammonia-lowering [L-ornithine-L-aspartate (LOLA)] or vigilance-enhancing medication (caffeine). Six patients with cirrhosis (5 males; 61.3 ± 9.2 years; 5 Child A, 1 Child B) and six healthy volunteers (5 males; 49.8 ± 10.6 years) were studied between 08:00 and 19:00 on Monday of three consecutive weeks.
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- Garrido, Maria
- Skorucak, Jelena
- Raduazzo, Daniela
- Turco, Matteo
- Spinelli, Giuseppe
- Angeli, Paolo
- Amodio, Piero
- Achermann, Peter
- Montagnese, Sara
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Garrido, M., Skorucak, J., Raduazzo, D., Turco, M., Spinelli, G., Angeli, P., Amodio, P., Achermann, P., & Montagnese, S. (2016). Vigilance and wake EEG architecture in simulated hyperammonaemia: a pilot study on the effects of L-Ornithine-L-Aspartate (LOLA) and caffeine. Metabolic Brain Disease, 31(4), 965–974. https://doi.org/10.1007/s11011-016-9835-9
