Associations of n-3 polyunsaturated fatty acid status and intake with paediatric major depressive disorder in Swiss adolescents: A case-control study

Osuna, Ester; Herter-Aeberli, Isabelle; Probst, Silvia; Emery, Sophie; Albermann, Mona; Baumgartner, Noemi; Strumberger, Michael; Ricci, Cristian; Schmeck, Klaus; Walitza, Susanne; Hersberger, Martin; Zimmermann, Michael B; Häberling, Isabelle; Berger, Gregor; Baumgartner, Jeannine

doi:10.5167/uzh-234721

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Osuna, E., Herter-Aeberli, I., Probst, S., Emery, S., Albermann, M., Baumgartner, N., Strumberger, M., Ricci, C., Schmeck, K., Walitza, S., Hersberger, M., Zimmermann, M. B., Häberling, I., Berger, G., & Baumgartner, J. (2023). Associations of n-3 polyunsaturated fatty acid status and intake with paediatric major depressive disorder in Swiss adolescents: A case-control study. Journal of Affective Disorders, 339, 355–365. https://doi.org/10.1016/j.jad.2023.07.046

Abstract

Background: Observational studies suggest a link between n-3 polyunsaturated fatty acid (PUFA) intake, n-3 PUFA status, and depression in adults, but studies in adolescents are scarce. This study aimed to determine associations of n-3 PUFA status and intake with paediatric major depressive disorder (pMDD) in Swiss adolescents.

Methods: We conducted a matched case-control study in 95 adolescents diagnosed with pMDD and 95 healthy controls aged 13 to <18 years. We analysed red blood cell (RBC) fatty acid (FA) composition (% of total FA