Publication: Autophagy in major human diseases
Autophagy in major human diseases
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Klionsky, D. J., Petroni, G., Amaravadi, R. K., et al, & Münz, C. (2021). Autophagy in major human diseases. The EMBO Journal, 40(19), e108863. https://doi.org/10.15252/embj.2021108863
Abstract
Abstract
Abstract
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, inf
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- Klionsky, Daniel J
- Petroni, Giulia
- Amaravadi, Ravi K
- Münz, Christian
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Klionsky, D. J., Petroni, G., Amaravadi, R. K., et al, & Münz, C. (2021). Autophagy in major human diseases. The EMBO Journal, 40(19), e108863. https://doi.org/10.15252/embj.2021108863
