Publication: Inhibitor of apoptosis protein-1 regulates tumor necrosis factor-mediated destruction of intestinal epithelial cells
Inhibitor of apoptosis protein-1 regulates tumor necrosis factor-mediated destruction of intestinal epithelial cells
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Grabinger, T., Bode, K. J., Demgenski, J., Seitz, C., Delgado, M. E., Kostadinova, F., Reinhold, C., Etemadi, N., Wilhelm, S., Schweinlin, M., Hänggi, K., Knop, J., Hauck, C., Walles, H., Silke, J., Wajant, H., Nachbur, U., Wong, W. W.-L., & Brunner, T. (2017). Inhibitor of apoptosis protein-1 regulates tumor necrosis factor-mediated destruction of intestinal epithelial cells. Gastroenterology, 152(4), 867–879. https://doi.org/10.1053/j.gastro.2016.11.019
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Background and aims: Tumor necrosis factor (TNF) is a cytokine that promotes inflammation and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and tissues, intestinal epithelial cells undergo rapid cell death upon exposure to TNF, by unclear mechanisms. We investigated the roles of inhibitor of apoptosis proteins (IAPs) in the regulation of TNF-induced cell death in the intestinal epithelium of mice and intestinal organoids. Methods: RNA from cell lines and tissues and analyzed by quantitative PCR, protei
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- Grabinger, T
- Bode, K J
- Demgenski, J
- Seitz, C
- Delgado, M E
- Kostadinova, F
- Reinhold, C
- Etemadi, N
- Wilhelm, S
- Schweinlin, M
- Hänggi, Kay
- Knop, J
- Hauck, C
- Walles, H
- Silke, J
- Wajant, H
- Nachbur, U
- Wong, W Wei-Lynn
- Brunner, T
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Grabinger, T., Bode, K. J., Demgenski, J., Seitz, C., Delgado, M. E., Kostadinova, F., Reinhold, C., Etemadi, N., Wilhelm, S., Schweinlin, M., Hänggi, K., Knop, J., Hauck, C., Walles, H., Silke, J., Wajant, H., Nachbur, U., Wong, W. W.-L., & Brunner, T. (2017). Inhibitor of apoptosis protein-1 regulates tumor necrosis factor-mediated destruction of intestinal epithelial cells. Gastroenterology, 152(4), 867–879. https://doi.org/10.1053/j.gastro.2016.11.019
