Publication: Preventive Trichuris suis ova (TSO) treatment protects immunocompetent rabbits from DSS colitis but may be detrimental under conditions of immunosuppression
Preventive Trichuris suis ova (TSO) treatment protects immunocompetent rabbits from DSS colitis but may be detrimental under conditions of immunosuppression
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Leonardi, I., Gerstgrasser, A., Schmidt, T. S. B., Nicholls, F., Tewes, B., Greinwald, R., von Mering, C., Rogler, G., & Frey-Wagner, I. (2017). Preventive Trichuris suis ova (TSO) treatment protects immunocompetent rabbits from DSS colitis but may be detrimental under conditions of immunosuppression. Scientific Reports, 7(1), 16500. https://doi.org/10.1038/s41598-017-16287-4
Abstract
Abstract
Abstract
Trichuris suis ova (TSO) have been tested for therapeutic application in inflammatory bowel diseases (IBD) yet understanding of the underlying mechanisms and safety in an immunocompromised host is limited due to lack of a suitable animal model. We used a recently established rabbit model of dextran sodium sulphate (DSS) induced colitis to study the efficacy, mechanisms and safety of TSO therapy in immunocompetent and immunosuppressed animals. TSO treatment prevented the DSS induced weight loss, delayed the onset of DSS induced symptom
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Creators (Authors)
- Leonardi, Irina
- Gerstgrasser, Alexandra
- Schmidt, Thomas S B
- Nicholls, Flora
- Tewes, Bernhard
- Greinwald, Roland
- Rogler, Gerhard
- Frey-Wagner, Isabelle
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Citations
Leonardi, I., Gerstgrasser, A., Schmidt, T. S. B., Nicholls, F., Tewes, B., Greinwald, R., von Mering, C., Rogler, G., & Frey-Wagner, I. (2017). Preventive Trichuris suis ova (TSO) treatment protects immunocompetent rabbits from DSS colitis but may be detrimental under conditions of immunosuppression. Scientific Reports, 7(1), 16500. https://doi.org/10.1038/s41598-017-16287-4
