Subgrouping children and adolescents with disruptive behaviors: symptom profiles and the role of callous-unemotional traits

Rosa-Justicia, Mireia; Saam, Melanie C; Flamarique, Itziar; Borràs, Roger; Naaijen, Jilly; Dietrich, Andrea; Hoekstra, Pieter J; Banaschewski, Tobias; Aggensteiner, Pascal; Craig, Michael C; Sethi, Arjun; Santosh, Paramala; Sagar-Ouriaghli, Ilyas; Arango, Celso; Penzol, María José; Brandeis, Daniel; Werhahn, Julia E; Glennon, Jeffrey C; Franke, Barbara; Zwiers, Marcel P

doi:10.5167/uzh-193612

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Rosa-Justicia, M., Saam, M. C., Flamarique, I., Borràs, R., Naaijen, J., Dietrich, A., Hoekstra, P. J., Banaschewski, T., Aggensteiner, P., Craig, M. C., Sethi, A., Santosh, P., Sagar-Ouriaghli, I., Arango, C., Penzol, M. J., Brandeis, D., Werhahn, J. E., Glennon, J. C., Franke, B., … Castro-Fornieles, J. (2022). Subgrouping children and adolescents with disruptive behaviors: symptom profiles and the role of callous-unemotional traits. European Child & Adolescent Psychiatry, 31, 51–66. https://doi.org/10.1007/s00787-020-01662-w

Abstract

Disruptive behavior during childhood and adolescence is heterogeneous and associated with several psychiatric disorders. The identification of more homogeneous subgroups might help identify different underlying pathways and tailor treatment strategies. Children and adolescents (aged 8-18) with disruptive behaviors (N = 121) and healthy controls (N = 100) were included in a European multi-center cognition and brain imaging study. They were assessed via a battery of standardized semi-structured interviews and questionnaires. K-means clu