Proliferation of ASC-derived endothelial cells in a 3D electrospun mesh: Impact of bone-biomimetic nanocomposite and co-culture with ASC-derived osteoblasts

Gao, Shuping; Calcagni, Maurizio; Welti, Manfred; Hemmi, Sonja; Hild, Nora; Stark, Wendelin J; Meier Bürgisser, Gabriella; Wanner, Guido A; Cinelli, Paolo; Buschmann, Johanna

doi:10.1016/j.injury.2014.02.035

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Gao, S., Calcagni, M., Welti, M., Hemmi, S., Hild, N., Stark, W. J., Meier Bürgisser, G., Wanner, G. A., Cinelli, P., & Buschmann, J. (2014). Proliferation of ASC-derived endothelial cells in a 3D electrospun mesh: Impact of bone-biomimetic nanocomposite and co-culture with ASC-derived osteoblasts. Injury, 45(6), 974–980. https://doi.org/10.1016/j.injury.2014.02.035

Abstract

BACKGROUND: Fractures with a critical size bone defect are associated with high rates of delayed- and non-union. The treatment of such complications remains a serious issue in orthopaedic surgery. Adipose derived stem cells (ASCs) combined with biomimetic materials can potentially be used to increase fracture healing. Nevertheless, a number of requirements have to be fulfilled; in particular, the insufficient vascularisation of the bone constructs. Here, the objectives were to study the impact of ASC-derived osteoblasts on ASC-derived