Publication: A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies
A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies
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Nijman, R. G., Oostenbrink, R., Moll, H. A., Casals-Pascual, C., von Both, U., et al, & Schlapbach, L. J. (2021). A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies. Frontiers in Pediatrics, 9, 688272. https://doi.org/10.3389/fped.2021.688272
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Background: The limited diagnostic accuracy of biomarkers in children at risk of a serious bacterial infection (SBI) might be due to the imperfect reference standard of SBI. We aimed to evaluate the diagnostic performance of a new classification algorithm for biomarker discovery in children at risk of SBI. Methods: We used data from five previously published, prospective observational biomarker discovery studies, which included patients aged 0- <16 years: the Alder Hey emergency department (n = 1,120), Alder Hey pediatric intensive ca
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- Nijman, Ruud G
- Oostenbrink, Rianne
- Moll, Henriette A
- Casals-Pascual, Climent
- von Both, Ulrich
- Schlapbach, Luregn J
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Nijman, R. G., Oostenbrink, R., Moll, H. A., Casals-Pascual, C., von Both, U., et al, & Schlapbach, L. J. (2021). A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies. Frontiers in Pediatrics, 9, 688272. https://doi.org/10.3389/fped.2021.688272
