Publication: Potent drug delivery enhancement of betulinic acid and NVX-207 into equine skin in vitro - a comparison between a novel oxygen flow-assisted transdermal application device and microemulsion gels
Potent drug delivery enhancement of betulinic acid and NVX-207 into equine skin in vitro - a comparison between a novel oxygen flow-assisted transdermal application device and microemulsion gels
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Zscherpe, P., Kalbitz, J., Weber, L. A., Paschke, R., Mäder, K., von Rechenberg, B., Cavalleri, J.-M. V., Meissner, J., & Klein, K. (2024). Potent drug delivery enhancement of betulinic acid and NVX-207 into equine skin in vitro - a comparison between a novel oxygen flow-assisted transdermal application device and microemulsion gels. BMC Veterinary Research, 20(1), 202. https://doi.org/10.1186/s12917-024-04064-1
Abstract
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BACKGROUND: Gray horses are predisposed to equine malignant melanoma (EMM) with advancing age. Depending on the tumor's location and size, they can cause severe problems (e.g., defaecation, urination, feeding). A feasible therapy for EMM has not yet been established and surgical excision can be difficult depending on the location of the melanoma. Thus, an effective and safe therapy is needed. Naturally occurring betulinic acid (BA), a pentacyclic triterpene and its synthetic derivate, NVX-207 (3-acetyl-betulinic acid-2-amino-3-hydroxy
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- Zscherpe, Paula
- Kalbitz, Jutta
- Weber, Lisa A
- Paschke, Reinhard
- Mäder, Karsten
- von Rechenberg, Brigitte
- Cavalleri, Jessika-M V
- Meissner, Jessica
- Klein, Karina
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Zscherpe, P., Kalbitz, J., Weber, L. A., Paschke, R., Mäder, K., von Rechenberg, B., Cavalleri, J.-M. V., Meissner, J., & Klein, K. (2024). Potent drug delivery enhancement of betulinic acid and NVX-207 into equine skin in vitro - a comparison between a novel oxygen flow-assisted transdermal application device and microemulsion gels. BMC Veterinary Research, 20(1), 202. https://doi.org/10.1186/s12917-024-04064-1
