Publication: Mannose-based molecular patterns on stealth microspheres for receptor-specific targeting of human antigen-presenting cells
Mannose-based molecular patterns on stealth microspheres for receptor-specific targeting of human antigen-presenting cells
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Wattendorf, U., Coullerez, G., Vörös, J., Textor, M., & Merkle, H. P. (2008). Mannose-based molecular patterns on stealth microspheres for receptor-specific targeting of human antigen-presenting cells. Langmuir, 24(20), 11790–11802. https://doi.org/10.1021/la801085d
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The targeting of antigen-presenting cells has recently gained strong attention for both targeted vaccine delivery and immunomodulation. We prepared surface-modified stealth microspheres that display various mannose-based ligands at graded ligand densities to target phagocytic C-type lectin receptors (CLRs) on human dendritic cells (DCs) and macrophages. Decoration of microspheres with carbohydrate ligands was achieved (i) by electrostatic surface assembly of mannan onto previously formed adlayers of poly(l-lysine) (PLL) or a mix of PL
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- Wattendorf, U
- Coullerez, G
- Vörös, J
- Textor, M
- Merkle, H P
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Wattendorf, U., Coullerez, G., Vörös, J., Textor, M., & Merkle, H. P. (2008). Mannose-based molecular patterns on stealth microspheres for receptor-specific targeting of human antigen-presenting cells. Langmuir, 24(20), 11790–11802. https://doi.org/10.1021/la801085d