Publication: Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins
Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins
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Turkington, H. L., Juozapaitis, M., Tsolakos, N., Corrales-Aguilar, E., Schwemmle, M., & Hale, B. G. (2018). Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins. Journal of Virology, 92(5), e02097-17. https://doi.org/10.1128/JVI.02097-17
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Abstract
Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV glycoproteins lack canonical receptor binding and destroying activity. Nevertheless, other features that distinguish these viruses from classical FLUAVs have yet to be explored. Here, we studied the viral non-structural protein, NS1, a virulence factor that modulates host signaling to promote efficient propagation. Like all FLUAV NS
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Turkington, H. L., Juozapaitis, M., Tsolakos, N., Corrales-Aguilar, E., Schwemmle, M., & Hale, B. G. (2018). Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins. Journal of Virology, 92(5), e02097-17. https://doi.org/10.1128/JVI.02097-17