Publication: Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process
Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process
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Ader-Ebert, N., Khosravi, M., Herren, M., Avila, M., Alves, L., Bringolf, F., Örvell, C., Langedijk, J. P., Zurbriggen, A., Plemper, R. K., & Plattet, P. (2015). Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process. PLoS Pathogens, 11, e1004880. https://doi.org/10.1371/journal.ppat.1004880
Abstract
Abstract
Abstract
Despite large vaccination campaigns, measles virus (MeV) and canine distemper virus (CDV) cause major morbidity and mortality in humans and animals, respectively. The MeV and CDV cell entry system relies on two interacting envelope glycoproteins: the attachment protein (H), consisting of stalk and head domains, co-operates with the fusion protein (F) to mediate membrane fusion. However, how receptor-binding by the H-protein leads to F-triggering is not fully understood. Here, we report that an anti-CDV-H monoclonal antibody (mAb-1347)
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- Ader-Ebert, Nadine
- Khosravi, Mojtaba
- Herren, Michael
- Avila, Mislay
- Alves, Lisa
- Bringolf, Fanny
- Örvell, Claes
- Langedijk, Johannes P
- Zurbriggen, Andreas
- Plemper, Richard K
- Plattet, Philippe
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Ader-Ebert, N., Khosravi, M., Herren, M., Avila, M., Alves, L., Bringolf, F., Örvell, C., Langedijk, J. P., Zurbriggen, A., Plemper, R. K., & Plattet, P. (2015). Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process. PLoS Pathogens, 11, e1004880. https://doi.org/10.1371/journal.ppat.1004880
