Publication: Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress
Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress
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Yang, K., Velagapudi, S., Akhmedov, A., Kraler, S., Lapikova-Bryhinska, T., Schmiady, M. O., Wu, X., Geng, L., Camici, G. G., Xu, A., & Lüscher, T. F. (2023). Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress. Cardiovascular Research, 119(12), 2190–2201. https://doi.org/10.1093/cvr/cvad102
Abstract
Abstract
Abstract
Aims Enhancing SIRT1 activity exerts beneficial cardiovascular effects. In diabetes, plasma SIRT1 levels are reduced. We aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supplementation to alleviate endothelial and vascular dysfunction in diabetic mice (db/db).
Methods and results Left internal mammary arteries obtained from patients undergoing coronary artery bypass grafting with or without a diagnosis of diabetes were assayed for SIRT1 protein levels. Twelve-week-old male d
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Creators (Authors)
- Yang, Kangmin
- Velagapudi, Srividya
- Akhmedov, Alexander
- Kraler, Simon
- Lapikova-Bryhinska, Tetiana
- Schmiady, Martin O
- Wu, Xiaoping
- Geng, Leiluo
- Camici, Giovanni G
- Xu, Aimin
- Lüscher, Thomas F
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Swiss Heart Foundation
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Yang, K., Velagapudi, S., Akhmedov, A., Kraler, S., Lapikova-Bryhinska, T., Schmiady, M. O., Wu, X., Geng, L., Camici, G. G., Xu, A., & Lüscher, T. F. (2023). Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress. Cardiovascular Research, 119(12), 2190–2201. https://doi.org/10.1093/cvr/cvad102
