Prefrontal microglia deficiency during adolescence disrupts adult cognitive functions and synaptic structure: A follow-up study in female mice

von Arx, Anina S; Dawson, Kara; Lin, Han-Yu; Mattei, Daniele; Notter, Tina; Meyer, Urs; Schalbetter, Sina M

doi:10.5167/uzh-253494

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von Arx, A. S., Dawson, K., Lin, H.-Y., Mattei, D., Notter, T., Meyer, U., & Schalbetter, S. M. (2023). Prefrontal microglia deficiency during adolescence disrupts adult cognitive functions and synaptic structure: A follow-up study in female mice. Brain, Behavior, and Immunity, 111, 230–246. https://doi.org/10.1016/j.bbi.2023.04.007

Abstract

The prefrontal cortex (PFC) provides executive top-down control of a variety of cognitive processes. A distinctive feature of the PFC is its protracted structural and functional maturation throughout adolescence to early adulthood, which is necessary for acquiring mature cognitive abilities. Using a mouse model of cell-specific, transient and local depletion of microglia, which is based on intracerebral injection of clodronate disodium salt (CDS) into the PFC of adolescent male mice, we recently demonstrated that microglia contribute