Publication: Hantavirus infection-induced B cell activation elevates free light chains levels in circulation
Hantavirus infection-induced B cell activation elevates free light chains levels in circulation
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Hepojoki, J., Cabrera, L. E., Hepojoki, S., Bellomo, C., Kareinen, L., Andersson, L. C., Vaheri, A., Mäkelä, S., Mustonen, J., Vapalahti, O., Martinez, V., & Strandin, T. (2021). Hantavirus infection-induced B cell activation elevates free light chains levels in circulation. PLoS Pathogens, 17(8), e1009843. https://doi.org/10.1371/journal.ppat.1009843
Abstract
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Abstract
In humans, orthohantaviruses can cause hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). An earlier study reported that acute Andes virus HPS caused a massive and transient elevation in the number of circulating plasmablasts with specificity towards both viral and host antigens suggestive of polyclonal B cell activation. Immunoglobulins (Igs), produced by different B cell populations, comprise heavy and light chains; however, a certain amount of free light chains (FLCs) is constantly present in serum
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- Hepojoki, Jussi
- Cabrera, Luz E
- Hepojoki, Satu
- Bellomo, Carla
- Kareinen, Lauri
- Andersson, Leif C
- Vaheri, Antti
- Mäkelä, Satu
- Mustonen, Jukka
- Vapalahti, Olli
- Martinez, Valeria
- Strandin, Tomas
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Hepojoki, J., Cabrera, L. E., Hepojoki, S., Bellomo, C., Kareinen, L., Andersson, L. C., Vaheri, A., Mäkelä, S., Mustonen, J., Vapalahti, O., Martinez, V., & Strandin, T. (2021). Hantavirus infection-induced B cell activation elevates free light chains levels in circulation. PLoS Pathogens, 17(8), e1009843. https://doi.org/10.1371/journal.ppat.1009843
