Publication: The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels.
The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels.
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Oldham, S., Stocker, H., Laffargue, M., Wittwer, F., Wymann, M. P., & Hafen, E. (2002). The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. Development, 129(17), 4103–4109.
Abstract
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Abstract
Understanding the control of size is of fundamental biological and clinical importance. Insulin/IGF signaling during development controls growth and size, possibly by coordinating the activities of the Ras and PI 3-kinase signaling pathways. We show that in Drosophila mutating the consensus binding site for the Ras pathway adaptor Drk/Grb2 in Chico/IRS does not interfere with growth whereas mutating the binding sites of the PI 3-kinase adaptor p60 completely abrogates Chico function. Furthermore, we present biochemical and genetic evi
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Creators (Authors)
- Oldham, S
- Stocker, H
- Laffargue, M
- Wittwer, F
- Hafen, E
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Citations
Oldham, S., Stocker, H., Laffargue, M., Wittwer, F., Wymann, M. P., & Hafen, E. (2002). The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. Development, 129(17), 4103–4109.
