Implications of TDP-43 RNA Binding in Physiology and Pathology

Abstract

TAR DNA-binding protein 43 (TDP-43) is a ubiquitously expressed RNA-binding protein of the hnRNP family. It consists of an N-terminal domain (NTD) that mediates its physiological oligomerization, two RNA recognition motifs (RRMs) that are crucial for the roles of TDP-43 in RNA processing, and an intrinsically disordered domain of low complexity (LCD) that is essential for TDP-43 liquid-liquid phase separation and renders it prone to aggregation. In healthy cells, TDP-43 primarily localizes to the nucleus, where it engages in physiolog Show more