Species fractionation in a case-control study concerning Parkinson’s disease: Cu-amino acids discriminate CSF of PD from controls

Willkommen, Desiree; Lucio, Marianna; Schmitt-Kopplin, Philippe; Gazzaz, Malaz; Schroeter, Michael; Sigaroudi, Ali; Michalke, Bernhard

doi:10.1016/j.jtemb.2018.01.005

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Willkommen, D., Lucio, M., Schmitt-Kopplin, P., Gazzaz, M., Schroeter, M., Sigaroudi, A., & Michalke, B. (2018). Species fractionation in a case-control study concerning Parkinson’s disease: Cu-amino acids discriminate CSF of PD from controls. Journal of Trace Elements in Medicine and Biology, 49, 164–170. https://doi.org/10.1016/j.jtemb.2018.01.005

Abstract

BACKGROUND: Parkinson's disease is affecting about 1% of the population above 65 years. Improvements in medicine support prolonged lifetime which increases the total concentration of humans affected by the disease. It is suggested that occupational and environmental exposure to metals like iron (Fe), manganese (Mn), copper (Cu) and zinc (Zn) can influence the risk for Parkinson's disease. These metals play a key role as cofactors in many enzymes and proteins. METHODS: In this case-control study, we investigated the Mn-, Fe-, Cu- and Z