Non-invasive accurate measurement of arterial PCO2 in a pediatric animal model

Fierstra, Jorn; Winter, Jeff D; Machina, Matthew; Lukovic, Jelena; Duffin, James; Kassner, Andrea; Fisher, Joseph A

doi:10.1007/s10877-012-9403-8

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Fierstra, J., Winter, J. D., Machina, M., Lukovic, J., Duffin, J., Kassner, A., & Fisher, J. A. (2013). Non-invasive accurate measurement of arterial PCO2 in a pediatric animal model. Journal of Clinical Monitoring and Computing, 27(2), 147–155. https://doi.org/10.1007/s10877-012-9403-8

Abstract

The PCO2 in arterial blood (PaCO2) is a good parameter for monitoring ventilation and acid-base changes in ventilated patients, but its measurement is invasive and difficult to obtain in small children. Attempts have been made to use the partial pressure of CO2 in end-tidal gas (PETCO2), as a noninvasive surrogate for PaCO2. Studies have revealed that, unfortunately, the differences between PETCO2 and PaCO2 are too variable to be clinically useful. We hypothesized that end-inspiratory rebreathing, previously shown to equalize PETCO2 a