Publication: FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and Metastasis through Cyclin D1
FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and Metastasis through Cyclin D1
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Kuzmanov, A., Johansen, P., & Hofbauer, G. (2020). FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and Metastasis through Cyclin D1. Journal of Investigative Dermatology, 140(12), 2496–2504. https://doi.org/10.1016/j.jid.2020.04.003
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FBPs are components of the SCF protein E3 ubiquitin ligase and can specifically bind to substrates and thereby regulate multiple tumor behaviors. However, the role of FBPs, FBXO25 in particular, in cutaneous squamous cell carcinoma (cSCC) has not been explored yet. In this study, we found FBXO25 to be highly expressed in cSCC in mice and in vitro, whereas it was significantly less expressed in normal keratinocytes. Stable silencing of FBXO25 in SCC13 cells led to reduced tumor growth, and the knockdown of FBXO25 was accompanied by dow
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- Kuzmanov, Aleksandar
- Hofbauer, Günther
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Kuzmanov, A., Johansen, P., & Hofbauer, G. (2020). FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and Metastasis through Cyclin D1. Journal of Investigative Dermatology, 140(12), 2496–2504. https://doi.org/10.1016/j.jid.2020.04.003
