MicroRNA expression profiling in the prefrontal cortex: putative mechanisms for the cognitive effects of adolescent high fat feeding

Labouesse, Marie A; Polesel, Marcello; Clementi, Elena; Müller, Flavia; Markkanen, Enni; Mouttet, Forouhar; Cattaneo, Annamaria; Richetto, Juliet

doi:10.1038/s41598-018-26631-x

Citations

Citation copied

Labouesse, M. A., Polesel, M., Clementi, E., Müller, F., Markkanen, E., Mouttet, F., Cattaneo, A., & Richetto, J. (2018). MicroRNA expression profiling in the prefrontal cortex: putative mechanisms for the cognitive effects of adolescent high fat feeding. Scientific Reports, 8(1), 8344. https://doi.org/10.1038/s41598-018-26631-x

Abstract

The medial prefrontal cortex (mPFC), master regulator of higher-order cognitive functions, is the only brain region that matures until late adolescence. During this period, the mPFC is sensitive to stressful events or suboptimal nutrition. For instance, high-fat diet (HFD) feeding during adolescence markedly impairs prefrontal-dependent cognition. It also provokes multiple changes at the cellular and synaptic scales within the mPFC, suggesting that major transcriptional events are elicited by HFD during this maturational period. The n