Publication: A protective allergy vaccine based on CpG- and protamine-containing PLGA microparticles
A protective allergy vaccine based on CpG- and protamine-containing PLGA microparticles
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Gómez, J. M. M., Fischer, S., Csaba, N., Kündig, T. M., Merkle, H. P., Gander, B., & Johansen, P. (2007). A protective allergy vaccine based on CpG- and protamine-containing PLGA microparticles. Pharmaceutical Research, 24(10), 1927–1935. https://doi.org/10.1007/s11095-007-9318-0
Abstract
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Purpose: Allergen-specific immunotherapy (SIT) requires dozens of subcutaneous injections over 3 to 5years in order to control IgE-mediated hypersensitivity, which is a T-helper 2 (Th2)-associated pathology. This study investigates the use of poly(lactide-co-glycolide) (PLGA) microparticles combined with immunostimulatory oligodeoxynucleotide (CpG), as well as protamine in SIT. Materials and Methods: We prepared microparticle formulations with the major allergen of bee venom, phospholipase A2 (PLA2), and analyzed the effect of co-enca
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- Gómez, Julia M Martínez
- Fischer, Stefan
- Csaba, Noèmi
- Kündig, Thomas M
- Merkle, Hans P
- Gander, Bruno
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Gómez, J. M. M., Fischer, S., Csaba, N., Kündig, T. M., Merkle, H. P., Gander, B., & Johansen, P. (2007). A protective allergy vaccine based on CpG- and protamine-containing PLGA microparticles. Pharmaceutical Research, 24(10), 1927–1935. https://doi.org/10.1007/s11095-007-9318-0
