Publication: Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
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Meccariello, A., Salvemini, M., Primo, P., Hall, B., Koskinioti, P., Dalíková, M., Gravina, A., Gucciardino, M. A., Forlenza, F., Gregoriou, M.-E., Ippolito, D., Monti, S. M., Petrella, V., Perrotta, M. M., Schmeing, S., Ruggiero, A., Scolari, F., Giordano, E., Tsoumani, K. T., … Saccone, G. (2019). Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests. Science, 365(6460), 1457–1460. https://doi.org/10.1126/science.aax1318
Abstract
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In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and
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- Meccariello, Angela
- Salvemini, Marco
- Primo, Pasquale
- Hall, Brantley
- Koskinioti, Panagiota
- Dalíková, Martina
- Gravina, Andrea
- Gucciardino, Michela Anna
- Forlenza, Federica
- Gregoriou, Maria-Eleni
- Ippolito, Domenica
- Monti, Simona Maria
- Petrella, Valeria
- Perrotta, Maryanna Martina
- Schmeing, Stephan
- Ruggiero, Alessia
- Scolari, Francesca
- Giordano, Ennio
- Tsoumani, Konstantina T
- Marec, František
- Windbichler, Nikolai
- Arunkumar, Kallare P
- Bourtzis, Kostas
- Mathiopoulos, Kostas D
- Ragoussis, Jiannis
- Vitagliano, Luigi
- Tu, Zhijian
- Papathanos, Philippos Aris
- Saccone, Giuseppe
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Meccariello, A., Salvemini, M., Primo, P., Hall, B., Koskinioti, P., Dalíková, M., Gravina, A., Gucciardino, M. A., Forlenza, F., Gregoriou, M.-E., Ippolito, D., Monti, S. M., Petrella, V., Perrotta, M. M., Schmeing, S., Ruggiero, A., Scolari, F., Giordano, E., Tsoumani, K. T., … Saccone, G. (2019). Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests. Science, 365(6460), 1457–1460. https://doi.org/10.1126/science.aax1318
