Publication: Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing
Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing
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Orjuela, S., Parker, H. R., Sajibu, S., Cereatti, F., Sauter, M., Buffoli, F., Robinson, M. D., & Marra, G. (2022). Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing. Epigenetics, 17(6), 677–694. https://doi.org/10.1080/15592294.2021.1952375
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Physiological ageing and tumorigenesis are both associated with epigenomic alterations in human tissue cells, the most extensively investigated of which entails de novo cytosine methylation (i.e., hypermethylation) within the CpG dinucleotides of CpG islands. Genomic regions that become hypermethylated during tumorigenesis are generally believed to overlap regions that acquire methylation in normal tissues as an effect of ageing. To define the extension of this overlap, we analysed the DNA methylomes of 48 large-bowel tissue samples t
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- Orjuela, Stephany
- Parker, Hannah R
- Sajibu, Sija
- Cereatti, Fabrizio
- Sauter, Matthias
- Buffoli, Federico
- Marra, Giancarlo
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Orjuela, S., Parker, H. R., Sajibu, S., Cereatti, F., Sauter, M., Buffoli, F., Robinson, M. D., & Marra, G. (2022). Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing. Epigenetics, 17(6), 677–694. https://doi.org/10.1080/15592294.2021.1952375