Publication: G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation
G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation
Date
Date
Date
Citations
de Vallière, C., Wang, Y., Eloranta, J. J., Vidal, S., Clay, I., Spalinger, M. R., Tcymbarevich, I., Terhalle, A., Ludwig, M.-G., Suply, T., Fried, M., Kullak-Ublick, G. A., Frey-Wagner, I., Scharl, M., Seuwen, K., Wagner, C. A., & Rogler, G. (2015). G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation. Inflammatory Bowel Diseases, 21(6), 1269–1281. https://doi.org/10.1097/MIB.0000000000000375
Abstract
Abstract
Abstract
BACKGROUND A novel family of proton-sensing G protein-coupled receptors, including OGR1, GPR4, and TDAG8, was identified to be important for physiological pH homeostasis and inflammation. Thus, we determined the function of proton-sensing OGR1 in the intestinal mucosa. METHODS OGR1 expression in colonic tissues was investigated in controls and patients with IBD. Expression of OGR1 upon cell activation was studied in the Mono Mac 6 (MM6) cell line and primary human and murine monocytes by real-time PCR. Ogr1 knockout mice were crossbre
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- de Vallière, Cheryl
- Wang, Yu
- Eloranta, Jyrki J
- Vidal, Solange
- Clay, Ieuan
- Spalinger, Marianne R
- Tcymbarevich, Irina
- Terhalle, Anne
- Ludwig, Marie-Gabrielle
- Suply, Thomas
- Fried, Michael
- Kullak-Ublick, Gerd A
- Frey-Wagner, Isabelle
- Scharl, Michael
- Seuwen, Klaus
- Wagner, Carsten A
- Rogler, Gerhard
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
de Vallière, C., Wang, Y., Eloranta, J. J., Vidal, S., Clay, I., Spalinger, M. R., Tcymbarevich, I., Terhalle, A., Ludwig, M.-G., Suply, T., Fried, M., Kullak-Ublick, G. A., Frey-Wagner, I., Scharl, M., Seuwen, K., Wagner, C. A., & Rogler, G. (2015). G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation. Inflammatory Bowel Diseases, 21(6), 1269–1281. https://doi.org/10.1097/MIB.0000000000000375
