Structural brain network characteristics in patients with episodic and chronic migraine

Michels, Lars; Koirala, Nabin; Groppa, Sergiu; Luechinger, Roger; Gantenbein, Andreas R; Sandor, Peter S; Kollias, Spyros; Riederer, Franz; Muthuraman, Muthuraman

doi:10.1186/s10194-021-01216-8

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Michels, L., Koirala, N., Groppa, S., Luechinger, R., Gantenbein, A. R., Sandor, P. S., Kollias, S., Riederer, F., & Muthuraman, M. (2021). Structural brain network characteristics in patients with episodic and chronic migraine. Journal of Headache and Pain, 22, 8. https://doi.org/10.1186/s10194-021-01216-8

Abstract

BACKGROUND

Migraine is a primary headache disorder that can be classified into an episodic (EM) and a chronic form (CM). Network analysis within the graph-theoretical framework based on connectivity patterns provides an approach to observe large-scale structural integrity. We test the hypothesis that migraineurs are characterized by a segregated network.

METHODS

19 healthy controls (HC), 17 EM patients and 12 CM patients were included. Cortical thickness and subcortical volumes were computed, and topology was analyzed using a graph