Modelling coronary flows: impact of differently measured inflow boundary conditions on vessel-specific computational hemodynamic profiles

Lodi Rizzini, Maurizio; Candreva, Alessandro; Chiastra, Claudio; Gallinoro, Emanuele; Calò, Karol; D'Ascenzo, Fabrizio; De Bruyne, Bernard; Mizukami, Takuya; Collet, Carlos; Gallo, Diego; Morbiducci, Umberto

doi:10.1016/j.cmpb.2022.106882

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Lodi Rizzini, M., Candreva, A., Chiastra, C., Gallinoro, E., Calò, K., D’Ascenzo, F., De Bruyne, B., Mizukami, T., Collet, C., Gallo, D., & Morbiducci, U. (2022). Modelling coronary flows: impact of differently measured inflow boundary conditions on vessel-specific computational hemodynamic profiles. Computer Methods and Programs in Biomedicine, 221, 106882. https://doi.org/10.1016/j.cmpb.2022.106882

Abstract

BACKGROUND AND OBJECTIVES

The translation of hemodynamic quantities based on wall shear stress (WSS) or intravascular helical flow into clinical biomarkers of coronary atherosclerotic disease is still hampered by the assumptions/idealizations required by the computational fluid dynamics (CFD) simulations of the coronary hemodynamics. In the resulting budget of uncertainty, inflow boundary conditions (BCs) play a primary role. Accordingly, in this study we investigated the impact of the approach adopted for in vivo coronary artery blo