Publication: AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
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Ghodke, I., Remisova, M., Furst, A., Kilic, S., Reina-San-Martin, B., Poetsch, A. R., Altmeyer, M., & Soutoglou, E. (2021). AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation. Molecular Cell, 81(12), 2596-2610.e7. https://doi.org/10.1016/j.molcel.2021.04.010
Abstract
Abstract
Abstract
p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53 signaling. Although 53BP1's function is well established in DNA double-strand break repair, how its role in p53 signaling is modulated remains poorly understood. Here, we identify the scaffolding protein AHNAK as a G1 phase-enriched interactor of 53BP1. We demonstrate that AHNAK binds to the 53BP1 oligomerization domain and controls its multimerization potential. Loss of AHNAK results in hyper-accumulation of 53BP1 on chromatin and enhanced phase separation,
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Creators (Authors)
- Ghodke, Indrajeet
- Remisova, Michaela
- Furst, Audrey
- Kilic, Sinan
- Reina-San-Martin, Bernardo
- Poetsch, Anna R
- Altmeyer, Matthias
- Soutoglou, Evi
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Citations
Ghodke, I., Remisova, M., Furst, A., Kilic, S., Reina-San-Martin, B., Poetsch, A. R., Altmeyer, M., & Soutoglou, E. (2021). AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation. Molecular Cell, 81(12), 2596-2610.e7. https://doi.org/10.1016/j.molcel.2021.04.010
