Publication: Molecular assembly of multifunctional Tc-99m radiopharmaceuticals using "clickable" amino acid derivatives
Molecular assembly of multifunctional Tc-99m radiopharmaceuticals using "clickable" amino acid derivatives
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Mindt, T. L., Struthers, H., Spingler, B., Brans, L., Tourwe, D., Garcia-Garayoa, E., & Schibli, R. (2010). Molecular assembly of multifunctional Tc-99m radiopharmaceuticals using “clickable” amino acid derivatives. ChemMedChem, 5(12), 2026–2038. https://doi.org/10.1002/cmdc.201000342
Abstract
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Synthetic strategies that enable the efficient and selective combination of different biologically active entities hold great promise for the development of multifunctional hybrid conjugates useful for biochemical and medical applications. Starting from side-chain-functionalized N(alpha)-propargyl lysine derivatives, conjugates containing a Tc-99m-based imaging probe for SPECT and two different moieties (e.g., tumor-targeting vectors, pharmacological modifiers, affinity tags, or second imaging probes) can be assembled using the Cu-I-c
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- Mindt, Thomas L
- Struthers, Harriet
- Brans, Luc
- Tourwe, Dirk
- Garcia-Garayoa, Elisa
- Schibli, Roger
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Citations
Mindt, T. L., Struthers, H., Spingler, B., Brans, L., Tourwe, D., Garcia-Garayoa, E., & Schibli, R. (2010). Molecular assembly of multifunctional Tc-99m radiopharmaceuticals using “clickable” amino acid derivatives. ChemMedChem, 5(12), 2026–2038. https://doi.org/10.1002/cmdc.201000342
