Publication: Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice
Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice
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Slijepcevic, D., Kaufman, C., Wichers, C. G. K., Gilglioni, E. H., Lempp, F. A., Duijst, S., de Waart, D. R., Oude Elferink, R. P. J., Mier, W., Stieger, B., Beuers, U., Urban, S., & van de Graaf, S. F. J. (2015). Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice. Hepatology, 62(1), 207–219. https://doi.org/10.1002/hep.27694
Abstract
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UNLABELLED: The Na(+) -taurocholate cotransporting polypeptide (NTCP) mediates uptake of conjugated bile acids (BAs) and is localized at the basolateral membrane of hepatocytes. It has recently been recognized as the receptor mediating hepatocyte-specific entry of hepatitis B virus and hepatitis delta virus. Myrcludex B, a peptide inhibitor of hepatitis B virus entry, is assumed to specifically target NTCP. Here, we investigated BA transport and Myrcludex B binding in the first Slc10a1-knockout mouse model (Slc10a1 encodes NTCP). Prim
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- Slijepcevic, Davor
- Kaufman, Christina
- Wichers, Catharina G K
- Gilglioni, Eduardo H
- Lempp, Florian A
- Duijst, Suzanne
- de Waart, Dirk R
- Oude Elferink, Ronald P J
- Mier, Walter
- Stieger, Bruno
- Beuers, Ulrich
- Urban, Stephan
- van de Graaf, Stan F J
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Slijepcevic, D., Kaufman, C., Wichers, C. G. K., Gilglioni, E. H., Lempp, F. A., Duijst, S., de Waart, D. R., Oude Elferink, R. P. J., Mier, W., Stieger, B., Beuers, U., Urban, S., & van de Graaf, S. F. J. (2015). Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice. Hepatology, 62(1), 207–219. https://doi.org/10.1002/hep.27694
