Publication: Unreserved application of epigenetic methods to define differences of DNA methylation between urinary cellular and cell-free DNA
Unreserved application of epigenetic methods to define differences of DNA methylation between urinary cellular and cell-free DNA
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Ghanjati, F., Beermann, A., Hermanns, T., Poyet, C., Araúzo-Bravo, M. J., Seifert, H.-H., Schmidtpeter, M., Goering, W., Sorg, R., Wernet, P., & Santourlidis, S. (2014). Unreserved application of epigenetic methods to define differences of DNA methylation between urinary cellular and cell-free DNA. Cancer Biomarkers: Section A of Disease Markers, 14(5), 295–302. https://doi.org/10.3233/CBM-140407
Abstract
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Abstract
Urinary DNA is increasingly gaining importance in diagnosis of urological malignancies. Especially cell-free DNA originating from apoptotic and necrotic cells of the early tumor could become a key target for early stage tumor diagnosis. Aberrant DNA methylation forms tumor cell characteristic epigenetic profiles which are covalently established before any tumor related aberration at transcriptional or protein level has occurred. In addition, these epigenetic signatures are alterably adapted to and accompanying the individual stages of
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- Ghanjati, Foued
- Beermann, Agnes
- Hermanns, Thomas
- Poyet, Cedric
- Araúzo-Bravo, Marcos J
- Seifert, Hans-Helge
- Schmidtpeter, Martin
- Goering, Wolfgang
- Sorg, Rüdiger
- Wernet, Peter
- Santourlidis, Simeon
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Ghanjati, F., Beermann, A., Hermanns, T., Poyet, C., Araúzo-Bravo, M. J., Seifert, H.-H., Schmidtpeter, M., Goering, W., Sorg, R., Wernet, P., & Santourlidis, S. (2014). Unreserved application of epigenetic methods to define differences of DNA methylation between urinary cellular and cell-free DNA. Cancer Biomarkers: Section A of Disease Markers, 14(5), 295–302. https://doi.org/10.3233/CBM-140407