Publication: Mitochondrial and mitochondrial‐independent pathways of myocardial cell death during ischaemia and reperfusion injury
Mitochondrial and mitochondrial‐independent pathways of myocardial cell death during ischaemia and reperfusion injury
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Davidson, S. M., Adameová, A., Barile, L., Cabrera‐Fuentes, H. A., Lazou, A., Pagliaro, P., Stensløkken, K., & Garcia‐Dorado, D. (2020). Mitochondrial and mitochondrial‐independent pathways of myocardial cell death during ischaemia and reperfusion injury. Journal of Cellular and Molecular Medicine, 24, 3795–3806. https://doi.org/10.1111/jcmm.15127
Abstract
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Abstract
Acute myocardial infarction causes lethal injury to cardiomyocytes during both ischaemia and reperfusion (IR). It is important to define the precise mechanisms by which they die in order to develop strategies to protect the heart from IR injury. Necrosis is known to play a major role in myocardial IR injury. There is also evidence for significant myocardial death by other pathways such as apoptosis, although this has been challenged. Mitochondria play a central role in both of these pathways of cell death, as either a causal mechanism
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- Davidson, Sean M
- Adameová, Adriana
- Barile, Lucio
- Cabrera‐Fuentes, Hector Alejandro
- Lazou, Antigone
- Pagliaro, Pasquale
- Stensløkken, Kåre‐Olav
- Garcia‐Dorado, David
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Davidson, S. M., Adameová, A., Barile, L., Cabrera‐Fuentes, H. A., Lazou, A., Pagliaro, P., Stensløkken, K., & Garcia‐Dorado, D. (2020). Mitochondrial and mitochondrial‐independent pathways of myocardial cell death during ischaemia and reperfusion injury. Journal of Cellular and Molecular Medicine, 24, 3795–3806. https://doi.org/10.1111/jcmm.15127
