Publication: Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction
Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction
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Demange, P. A., Malanchini, M., Mallard, T. T., Biroli, P., Cox, S. R., Grotzinger, A. D., Tucker-Drob, E. M., Abdellaoui, A., Arseneault, L., van Bergen, E., Boomsma, D. I., Caspi, A., Corcoran, D. L., Domingue, B. W., Harris, K. M., Ip, H. F., Mitchell, C., Moffitt, T. E., Poulton, R., … Nivard, M. G. (2021). Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. Nature Genetics, 53(1), 35–44. https://doi.org/10.1038/s41588-020-00754-2
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Little is known about the genetic architecture of traits affecting educational attainment other than cognitive ability. We used genomic structural equation modeling and prior genome-wide association studies (GWASs) of educational attainment (n = 1,131,881) and cognitive test performance (n = 257,841) to estimate SNP associations with educational attainment variation that is independent of cognitive ability. We identified 157 genome-wide-significant loci and a polygenic architecture accounting for 57% of genetic variance in educational
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- Demange, Perline A
- Malanchini, Margherita
- Mallard, Travis T
- Cox, Simon R
- Grotzinger, Andrew D
- Tucker-Drob, Elliot M
- Abdellaoui, Abdel
- Arseneault, Louise
- van Bergen, Elsje
- Boomsma, Dorret I
- Caspi, Avshalom
- Corcoran, David L
- Domingue, Benjamin W
- Harris, Kathleen Mullan
- Ip, Hill F
- Mitchell, Colter
- Moffitt, Terrie E
- Poulton, Richie
- Prinz, Joseph A
- Sugden, Karen
- Wertz, Jasmin
- Williams, Benjamin S
- de Zeeuw, Eveline L
- Belsky, Daniel W
- Harden, K Paige
- Nivard, Michel G
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Demange, P. A., Malanchini, M., Mallard, T. T., Biroli, P., Cox, S. R., Grotzinger, A. D., Tucker-Drob, E. M., Abdellaoui, A., Arseneault, L., van Bergen, E., Boomsma, D. I., Caspi, A., Corcoran, D. L., Domingue, B. W., Harris, K. M., Ip, H. F., Mitchell, C., Moffitt, T. E., Poulton, R., … Nivard, M. G. (2021). Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. Nature Genetics, 53(1), 35–44. https://doi.org/10.1038/s41588-020-00754-2
