Platelet-rich plasma as a potential prophylactic measure against frozen shoulder in an in vivo shoulder contracture model

Feusi, Oscar; Karol, Agnieszka; Fleischmann, Thea; von Rechenberg, Brigitte; Bouaicha, Samy; Werner, Clement M L; Jentzsch, Thorsten

doi:10.1007/s00402-020-03617-x

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Feusi, O., Karol, A., Fleischmann, T., von Rechenberg, B., Bouaicha, S., Werner, C. M. L., & Jentzsch, T. (2022). Platelet-rich plasma as a potential prophylactic measure against frozen shoulder in an in vivo shoulder contracture model. Archives of Orthopaedic and Trauma Surgery, 142(3), 363–372. https://doi.org/10.1007/s00402-020-03617-x

Abstract

INTRODUCTION: Frozen shoulder (adhesive capsulitis) is a common painful and functionally-limiting disease affecting around 2% of the population. So far, therapeutic options are limited and often unsatisfactory. Platelet-rich plasma (PRP) has been used as a treatment option in other orthopedic diseases since it contains growth factors that stimulate tissue repair. So far, the effect of PRP on frozen shoulder lacks evidence. We hypothesized that PRP may be valuable in the prophylaxis and treatment of secondary frozen shoulder due to cap