Publication: Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats
Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats
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Khera, N., Ghayor, C., Lindholm, A. K., Pavlova, E., Atanassova, N., & Weber, F. E. (2020). Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats. Frontiers in Physiology, 11, 601084. https://doi.org/10.3389/fphys.2020.601084
Abstract
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Abstract
Development of an effective male contraceptive agent remains a challenge. The present study evaluates the potential of N, N-Dimethylacetamide (DMA), a FDA approved excipient as a male contraceptive agent. Male Sprague Dawley rats injected with DMA for a period of 8 weeks (one injection per week) showed a significant alteration of reproductive parameters. Furthermore, DMA treated animals showed complete infertility in a dose dependent manner, as no pups were born despite proper mating between females and DMA treated males. However, sto
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- Khera, Nupur
- Ghayor, Chafik
- Lindholm, Anna K
- Pavlova, Ekaterina
- Atanassova, Nina
- Weber, Franz E
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Khera, N., Ghayor, C., Lindholm, A. K., Pavlova, E., Atanassova, N., & Weber, F. E. (2020). Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats. Frontiers in Physiology, 11, 601084. https://doi.org/10.3389/fphys.2020.601084
