Publication: Multi-Omics Approach to Mitochondrial DNA Damage in Human Muscle Fibers
Multi-Omics Approach to Mitochondrial DNA Damage in Human Muscle Fibers
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Elstner, M., Olszewski, K., Prokisch, H., Klopstock, T., & Murgia, M. (2021). Multi-Omics Approach to Mitochondrial DNA Damage in Human Muscle Fibers. International Journal of Molecular Sciences, 22(20), 11080. https://doi.org/10.3390/ijms222011080
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Abstract
Mitochondrial DNA deletions affect energy metabolism at tissue-specific and cell-specific threshold levels, but the pathophysiological mechanisms determining cell fate remain poorly understood. Chronic progressive external ophthalmoplegia (CPEO) is caused by mtDNA deletions and characterized by a mosaic distribution of muscle fibers with defective cytochrome oxidase (COX) activity, interspersed among fibers with retained functional respiratory chain. We used diagnostic histochemistry to distinguish COX-negative from COX-positive fiber
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- Elstner, Matthias
- Olszewski, Konrad
- Prokisch, Holger
- Klopstock, Thomas
- Murgia, Marta
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Elstner, M., Olszewski, K., Prokisch, H., Klopstock, T., & Murgia, M. (2021). Multi-Omics Approach to Mitochondrial DNA Damage in Human Muscle Fibers. International Journal of Molecular Sciences, 22(20), 11080. https://doi.org/10.3390/ijms222011080
