Comparison of the pharmacodynamics of protamine zinc insulin and insulin degludec and validation of the continuous glucose monitoring system iPro2 in healthy cats

Salesov, Elena; Zini, Eric; Riederer, A; Lutz, Thomas A; Reusch, Claudia E

doi:10.1016/j.rvsc.2018.01.019

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Salesov, E., Zini, E., Riederer, A., Lutz, T. A., & Reusch, C. E. (2018). Comparison of the pharmacodynamics of protamine zinc insulin and insulin degludec and validation of the continuous glucose monitoring system iPro2 in healthy cats. Research in Veterinary Science, 118, 79–85. https://doi.org/10.1016/j.rvsc.2018.01.019

Abstract

With the aim to improve current therapeutic and monitoring options for diabetic cats, the present study compared pharmacodynamic parameters of protamine zinc insulin (PZI) and insulin degludec and validated the continuous glucose monitoring system (CGMS) iPro2 with Sof-sensor and Enlite-sensor focusing on the low glycemic range. Three doses (0.1, 0.2 and 0.3IU/kg) of the two insulin preparations and the CGMS iPro2 with two different sensors were tested in six healthy cats. After each insulin administration, onset of action, time to gl