Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain

Gottschalk, Sven; Degtyaruk, Oleksiy; Mc Larney, Benedict; Rebling, Johannes; Hutter, Magdalena Anastasia; Deán-Ben, Xosé Luís; Shoham, Shy; Razansky, Daniel

doi:10.1038/s41551-019-0372-9

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Gottschalk, S., Degtyaruk, O., Mc Larney, B., Rebling, J., Hutter, M. A., Deán-Ben, X. L., Shoham, S., & Razansky, D. (2019). Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain. Nature Biomedical Engineering, 3(5), 392–401. https://doi.org/10.1038/s41551-019-0372-9

Abstract

Efforts to scale neuroimaging towards the direct visualization of mammalian brain-wide neuronal activity have faced major challenges. Although high-resolution optical imaging of the whole brain in small animals has been achieved ex vivo, the real-time and direct monitoring of large-scale neuronal activity remains difficult, owing to the performance gap between localized, largely invasive, optical microscopy of rapid, cellular-resolved neuronal activity and whole-brain macroscopy of slow haemodynamics and metabolism. Here, we demonstra