Publication: Glucocorticoid Receptor Beta and Its Prognostic Value on Treatment Response in Chronic Vulvar Dermatitis
Glucocorticoid Receptor Beta and Its Prognostic Value on Treatment Response in Chronic Vulvar Dermatitis
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Bernays, V., Kowalewski, M. P., Dedes, I., Kerl French, K., Fink, D., Kolm, I., & Betschart, C. (2021). Glucocorticoid Receptor Beta and Its Prognostic Value on Treatment Response in Chronic Vulvar Dermatitis. Skin Pharmacology and Physiology, 34(1), 30–37. https://doi.org/10.1159/000513594
Abstract
Abstract
Abstract
Background: Chronic vulvar dermatitis (CVD) is the most prevalent disease in gynecologic dermatology. The treatment mainly depends on topical glucocorticoids (TGC) but is challenged by insufficient treatment response. On a histological level, the upregulation of the glucocorticoid receptor β (GRβ), an inhibitor of the active glucocorticoid receptor α (GRα), is discussed as mechanism of glucocorticoid insensitivity. Objectives: To analyze whether the expression of GRβ protein at baseline in keratinocytes may predict responsiveness to T
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Creators (Authors)
- Bernays, Valerie
- Kowalewski, Mariusz Pawel
- Dedes, Ioannis
- Kerl French, Katrin
- Fink, Daniel
- Kolm, Isabel
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Citations
Bernays, V., Kowalewski, M. P., Dedes, I., Kerl French, K., Fink, D., Kolm, I., & Betschart, C. (2021). Glucocorticoid Receptor Beta and Its Prognostic Value on Treatment Response in Chronic Vulvar Dermatitis. Skin Pharmacology and Physiology, 34(1), 30–37. https://doi.org/10.1159/000513594
