Publication: Translation from unconventional 5′ start sites drives tumour initiation
Translation from unconventional 5′ start sites drives tumour initiation
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Sendoel, A., Dunn, J. G., Rodriguez, E. H., Naik, S., Gomez, N. C., Hurwitz, B., Levorse, J., Dill, B. D., Schramek, D., Molina, H., Weissman, J. S., & Fuchs, E. (2017). Translation from unconventional 5′ start sites drives tumour initiation. Nature, 541(7638), 494–499. https://doi.org/10.1038/nature21036
Abstract
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Abstract
We are just beginning to understand how translational control affects tumour initiation and malignancy. Here we use an epidermis-specific, in vivo ribosome profiling strategy to investigate the translational landscape during the transition from normal homeostasis to malignancy. Using a mouse model of inducible SOX2, which is broadly expressed in oncogenic RAS-associated cancers, we show that despite widespread reductions in translation and protein synthesis, certain oncogenic mRNAs are spared. During tumour initiation, the transla
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- Sendoel, Ataman
- Dunn, Joshua G
- Rodriguez, Edwin H
- Naik, Shruti
- Gomez, Nicholas C
- Hurwitz, Brian
- Levorse, John
- Dill, Brian D
- Schramek, Daniel
- Molina, Henrik
- Weissman, Jonathan S
- Fuchs, Elaine
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Sendoel, A., Dunn, J. G., Rodriguez, E. H., Naik, S., Gomez, N. C., Hurwitz, B., Levorse, J., Dill, B. D., Schramek, D., Molina, H., Weissman, J. S., & Fuchs, E. (2017). Translation from unconventional 5′ start sites drives tumour initiation. Nature, 541(7638), 494–499. https://doi.org/10.1038/nature21036
