Publication: CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
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Shimokawa, N., Haglund, K., Hölter, S. M., Grabbe, C., Kirkin, V., Koibuchi, N., Schultz, C., Rozman, J., Hoeller, D., Qiu, C. H., Londoño, M. B., Ikezawa, J., Jedlicka, P., Stein, B., Schwarzacher, S. W., Wolfer, D. P., Ehrhardt, N., Heuchel, R., Nezis, I., … Dikic, I. (2010). CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. The EMBO Journal, 29(14), 2421–2432. https://doi.org/10.1038/emboj.2010.120
Abstract
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Abstract
Despite extensive investigations of Cbl-interacting protein of 85 kDa (CIN85) in receptor trafficking and cytoskeletal dynamics, little is known about its functions in vivo. Here, we report the study of a mouse deficient of the two CIN85 isoforms expressed in the central nervous system, exposing a function of CIN85 in dopamine receptor endocytosis. Mice lacking CIN85 exon 2 (CIN85(Deltaex2)) show hyperactivity phenotypes, characterized by increased physical activity and exploratory behaviour. Interestingly, CIN85(Deltaex2) animals dis
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Creators (Authors)
- Shimokawa, N
- Haglund, K
- Hölter, S M
- Grabbe, C
- Kirkin, V
- Koibuchi, N
- Schultz, C
- Rozman, J
- Hoeller, D
- Qiu, C H
- Londoño, M B
- Ikezawa, J
- Jedlicka, P
- Stein, B
- Schwarzacher, S W
- Wolfer, D P
- Ehrhardt, N
- Heuchel, R
- Nezis, I
- Brech, A
- Schmidt, M H H
- Fuchs, H
- Gailus-Durner, V
- Klingenspor, M
- Bogler, O
- Wurst, W
- Deller, T
- de Angelis, M H
- Dikic, I
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Shimokawa, N., Haglund, K., Hölter, S. M., Grabbe, C., Kirkin, V., Koibuchi, N., Schultz, C., Rozman, J., Hoeller, D., Qiu, C. H., Londoño, M. B., Ikezawa, J., Jedlicka, P., Stein, B., Schwarzacher, S. W., Wolfer, D. P., Ehrhardt, N., Heuchel, R., Nezis, I., … Dikic, I. (2010). CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. The EMBO Journal, 29(14), 2421–2432. https://doi.org/10.1038/emboj.2010.120
